Certain changes such as updates to IIS configuration schema, registry keys or .NET assemblies in GAC requires restarting IIS (iisreset). Alternatively, you can recycle application pools.
IIS uses site bindings to redirect traffic to corresponding web applications. Site bindings depend on listener adapters. The most common listener adapters (site binding types) are http, https, and ftp.
In some cases, you may want to use uncommon listener adapters such as net.tcp, net.pipe, net.msmq, and msmq.formatname. If you configure IIS correctly, you should see all of these adapters in the “Add Site Binding” window: